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991.
Rongqiang Liao Yulin Zhao Xiali Liao Manshuo Liu Chuanzhu Gao Jian Yang Bo Yang 《先进技术聚合物》2015,26(5):487-494
The efficient tumor targeting drug carrier was designed by bioconjugation of folic acid to β‐cyclodextrin through a polyamine cationic spacer. The characterization and inclusion complexation behavior of the inclusion complex of hydrophobic drug scutellarin with folic acid‐polyamine‐β‐cyclodextrin were investigated in both solution and solid state by means of phase‐solubility, nuclear magnetic resonance, X‐ray power diffraction, thermal gravimetric analysis, and scanning electron microscopy. Besides, the solubilization efficiency and antitumor activity of the inclusion complex were tested by saturated solution and MTT (Thiazole blue) method. Solubility and antitumor activity studies showed higher solubilizing ability and antitumor activity of the inclusion complex in comparison to free scutellarin. The folic acid‐polyamine‐β‐cyclodextrin that is presented may be promising active tumor‐targeting carrier candidates via folate mediation. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
992.
Won Sohn Jonghwa Kim So Hee Kang Se Ra Yang Ju-Yeon Cho Hyun Chin Cho Sang Goon Shim Yong-Han Paik 《Experimental & molecular medicine》2015,47(9):e184
Recent studies have shown that circulating microRNAs are a potential biomarker in various types of malignancies. The aim of this study was to investigate the feasibility of using serum exosomal microRNAs as novel serological biomarkers for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). We measured the serum exosomal microRNAs and serum circulating microRNAs in patients with CHB (n=20), liver cirrhosis (LC) (n=20) and HCC (n=20). Serum exosomal microRNA was extracted from 500 μl of serum using an Exosome RNA Isolation kit. The expression levels of microRNAs were quantified by real-time PCR. The expression levels of selected microRNAs were normalized to Caenorhabditis elegans microRNA (Cel-miR-39). The serum levels of exosomal miR-18a, miR-221, miR-222 and miR-224 were significantly higher in patients with HCC than those with CHB or LC (P<0.05). Further, the serum levels of exosomal miR-101, miR-106b, miR-122 and miR-195 were lower in patients with HCC than in patients with CHB (P=0.014, P<0.001, P<0.001 and P<0.001, respectively). There was no significant difference in the levels of miR-21 and miR-93 among the three groups. Additionally, the serum levels of circulating microRNAs showed a smaller difference between HCC and either CHB or LC. This study suggests that serum exosomal microRNAs may be used as novel serological biomarkers for HCC. 相似文献
993.
A Preloaded Amorphous Calcium Carbonate/Doxorubicin@Silica Nanoreactor for pH‐Responsive Delivery of an Anticancer Drug 下载免费PDF全文
Dr. Yang Zhao Dr. Zhong Luo Menghuan Li Qiuyu Qu Xing Ma Prof. Shu‐Hong Yu Prof. Yanli Zhao 《Angewandte Chemie (International ed. in English)》2015,54(3):919-922
Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH‐responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica was developed for drug delivery for use in cancer therapy. As a result of its rationally engineered structure, this nanoreactor maintains a low drug leakage in physiological and lysosomal/endosomal environments, and responds specifically to pH 6.5 to release the drug. This unique ACC–DOX@silica nanoreactor releases DOX precisely in the weakly acidic microenvironment of cancer cells and results in efficient cell death, thus showing its great potential as a desirable chemotherapeutic nanosystem for cancer therapy. 相似文献
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996.
Integrative Chemical Biology Approaches for Identification and Characterization of “Erasers” for Fatty‐Acid‐Acylated Lysine Residues within Proteins 下载免费PDF全文
Zheng Liu Tangpo Yang Xin Li Tao Peng Prof. Howard C. Hang Prof. Xiang David Li 《Angewandte Chemie (International ed. in English)》2015,54(4):1149-1152
Acylation of proteins with fatty acids is important for the regulation of membrane association, trafficking, subcellular localization, and activity of many cellular proteins. While significant progress has been made in our understanding of the two major forms of protein acylation with fatty acids, N‐myristoylation and S‐palmitoylation, studies of the acylation of lysine residues, within proteins, with fatty acids have lagged behind. Demonstrated here is the use of integrative chemical biology approaches to examine human sirtuins as de‐fatty‐acid acylases in vitro and in cells. Photo‐crosslinking chemistry is used to investigate enzymes which recognize fatty‐acid acylated lysine. Human Sirt2 was identified as a robust lysine de‐fatty‐acid acylase in vitro. The results also show that Sirt2 can regulate the acylation of lysine residues, of proteins, with fatty acids within cells. 相似文献
997.
Dr. Catherine Adam Dr. Lixu Yang Dr. Scott L. Cockroft 《Angewandte Chemie (International ed. in English)》2015,54(4):1164-1167
Fluorocarbons often have distinct miscibility properties compared to their nonfluorinated analogues. These differences may be attributed to van der Waals dispersion forces or solvophobic effects, but their contributions are notoriously difficult to separate in molecular recognition processes. Here, molecular torsion balances were used to compare cohesive alkyl and perfluoroalkyl interactions in a range of solvents. A simple linear regression enabled the energetic partitioning of solvophobic and van der Waals forces in the self‐association of apolar chains. The contributions of dispersion interactions in apolar cohesion were found to be strongly attenuated in solution compared to the gas phase, but still play a major role in fluorous and organic solvents. In contrast, solvophobic effects were found to be dominant in driving the association of apolar chains in aqueous solution. The results are expected to assist the computational modelling of van der Waals forces in solution. 相似文献
998.
Dr. Guang‐Ping Hao Giovanni Mondin Dr. Zhikun Zheng Tim Biemelt Stefan Klosz René Schubel Prof. Alexander Eychmüller Prof. Stefan Kaskel 《Angewandte Chemie (International ed. in English)》2015,54(6):1941-1945
There is significant interest in high‐performance materials that can directly and efficiently capture water vapor, particularly from air. Herein, we report a class of novel porous carbon cuboids with unusual ultra‐hydrophilic properties, over which the synergistic effects between surface heterogeneity and micropore architecture is maximized, leading to the best atmospheric water‐capture performance among porous carbons to date, with a water capacity of up to 9.82 mmol g?1 at P/P0=0.2 and 25 °C (20 % relative humidity or 6000 ppm). Benefiting from properties, such as defined morphology, narrow pore size distribution, and high heterogeneity, this series of functional carbons may serve as model materials for fundamental research on carbon chemistry and the advance of new types of materials for water‐vapor capture as well as other applications requiring combined highly hydrophilic surface chemistry, developed hierarchical porosity, and excellent stability. 相似文献
999.
Direct Conversion of Bulk Metals to Size‐Tailored,Monodisperse Spherical Non‐Coinage‐Metal Nanocrystals 下载免费PDF全文
Rui‐Chun Luo Chao Li Prof. Xi‐Wen Du Prof. Jing Yang 《Angewandte Chemie (International ed. in English)》2015,54(16):4787-4791
Monodisperse non‐noble metal nanocrystals (NCs) that are highly uniform in shapes and particle size are much desired in various advanced applications, and are commonly prepared by either thermal decomposition or reduction, where reactive organometallic precursors or/and strong reducing agents are mandatory; however, these are usually toxic, costly, or suffer a lack of availability. Bulk Group 12 metals can now be converted into ligand‐protected, highly crystalline, monodisperse spherical metal NCs with precisely controlled sizes without using any precursors and reducers. The method is based on low‐power NIR‐laser‐induced size‐selective layer‐by‐layer surface vaporization. The monodisperse Cd NCs show pronounced deep‐UV (DUV) localized surface plasmon resonance making them highly competitive DUV‐plasmonic materials. This approach will promote appreciably the emergence of a wide range of monodisperse technically important non‐coinage metal NCs with compelling functionalities. 相似文献
1000.
Direct Insight into the Three‐Dimensional Internal Morphology of Solid–Liquid–Vapor Interfaces at Microscale 下载免费PDF全文
Dr. Shuai Yang Jiexing Du Dr. Moyuan Cao Dr. Xi Yao Dr. Jie Ju Dr. Xu Jin Prof. Bin Su Prof. Kesong Liu Prof. Lei Jiang 《Angewandte Chemie (International ed. in English)》2015,54(16):4792-4795
Solid–liquid–vapor interfaces dominated by the three‐phase contact line, usually performing as the active center in reactions, are important in biological and industrial processes. In this contribution, we provide direct three‐dimensional (3D) experimental evidence for the inside morphology of interfaces with either Cassie or Wenzel states at micron level using X‐ray micro‐computed tomography, which allows us to accurately “see inside” the morphological structures and quantitatively visualize their internal 3D fine structures and phases in intact samples. Furthermore, the in‐depth measurements revealed that the liquid randomly and partly located on the top of protrusions on the natural and artificial superhydrophobic surfaces in Cassie regime, resulting from thermodynamically optimal minimization of the surface energy. These new findings are useful for the optimization of classical wetting theories and models, which should promote the surface scientific and technological developments. 相似文献